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What is Pepsin ?
- Sep 05, 2017 -

Pepsin is one of the principal protein degrading or proteolytic enzymes in the digestive system. During the process of digestion, Pepsin acts on the complex dietary protein and breaks up into peptides and amino acids which can be readily absorbed by the intestinal lining.

  PEPSIN enzyme produced in the mucosal lining of the stomach that acts to degrade protein. Pepsin is one of three principal protein-degrading, or proteolytic, enzymes in the digestive system , the other two being chymotrypsin and trypsin. The three enzymes were among the first to be isolated in crystalline form.

During the process of digestion, these enzymes, each of which is particularly effective in severing links between particular types of amino acids, collaborate to break down dietary proteins to their components, i.e., peptides and amino acids , which can be readily absorbed by the intestinal lining. In the laboratory studies pepsin is most efficient in cleaving bonds involving the aromatic amino acids, phenylalanine, tryptophan, and tyrosine.

Pepsin is synthesized in an inactive form by the stomach lining; hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin and other proteolytic enzymes are used in the laboratory analysis of various proteins; Pepsin is a gastric protease active at acidic pH, and formed by partial proteolysis of its inactive zymogens- the pepsinogens.

  Pepsin is manufactured from the frozen intestinal mucosa. The processes involve the controlled activation of glands followed by filtration, purification and finally spray drying to a fine powder in totally controlled conditions.

  Pepsin is a compact spherical molecule having mol wt = 35,500 Daltons.

  Pepsin has an excellent digestion power. Pepsin cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine and tyrosine.

  Pepsin has a very strong fibrinolytic and caseionolytic activity this in combination with starch degrading enzyme –amylase and lipid degrading enzyme – lipase acts as very good digestive aid.

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