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What Is Hyaluronic Acid /Sodium Hyaluronate ?
- Sep 06, 2017 -

What IsHyaluronic Acid ?

Hyaluronic Acid; or HA is a natural substance that is plentiful in our bodies when we are born.
It is found in all human connective tissue.

Hyaluronic Acid (HA) is a mucopolysaccharide composed of repeated disaccharide units of N-acetylglucosamine and glucuronic acid. The commercial HA is commonly a sodium form, called sodium hyaluronate. HA is widely presents in the extracellular matrix of animal tissues and vitreous humor. Its main physiological function is water retention and lubrication.

What Does Hyaluronic Acid Do ?

Hyaluronic Acid occurs naturally in the deeper layers of our skin (the dermis). It helps to keep skin smooth and "plump" through its ability to hold up to 1,000 times its weight in water.
It lubricates the joints.
Hyaluronic Acid plays a critical role in the rapid repair of wounds and other skin conditions.
Improves eye-sight 

1. Moisture Retention

The ability to retain and hold moisture is the secret to youthful, healthy, vibrant skin.

Aging robs us of this innate ability to hold in moisture. As we get older our bodies produce less and less HA. The drop in HA starts at around the age of 18-20 years. But after the age of 40 the down slide becomes apparent. Skin starts to lose its elasticity and lines and wrinkles appear.

HA also supports the formation and maintenance of collagen, an important connective tissue. Collagen degradation is believed to cause a decrease in skin tone and elasticity.

Healthy, youthful skin comes from the inside. By replacing the components that naturally deplete with age, we can reverse the signs associated with aging.

HA supplementation puts back in what is naturally lost to restore radiance and youth.

2. Joint Lubrication

HA occurs throughout the body in abundant amounts in many of the places people with hereditary connective tissue disorders have problems such as joints, heart valves and eyes. Hyaluronic acid abnormalities are a common thread in connective tissue disorders e.g osteoarthritis

3. Wound repair

Another important part of good skin is the ability to quickly heal wounds. This ability is slowly degraded with age. In part, it is due to the slowing down of cell mitosis, crucial aspect of cellular repair and regeneration. A possible contributing factor is also the decrease in the amount of HA available in the body.

4. Vision

HA makes up 80% of the human eye - it is present in the vitreous humor of the eye and assists in vision. HA is a shock absorber to the retina thus helping to prevent trauma to the eye.


Food supplements:

Hyaluronan through oral administration can increase the precursor of hyaluronan synthesis in vivo after the digestion and absorption, which will promote the generation of hyaluronan in the skin and other tissues and thus enable the skin to increase its water retention property, improve its elasticity and reduce wrinkles. 

Medical applications:

Hyaluronan could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and retinal detachment repair.

Hyaluronan can also be used to treat osteoarthritis of the knee. It is injected into the knee joint to supplement the viscosity of the joint fluid, thereby lubricate the joint, cushion the joint and produce an analgesic effect.

Hyaluronan has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the hyaluronan to facilitate the cell migration into the wound.

Hyaluronan is also used in anti-adhesive products, which are widely used in pelvic and abdominal surgery to prevent postoperative adhesions.

Cosmetics applications:

Hyaluronan has outstanding moisture keeping ability, thus is called natural moisturing factor in the world. It can be used as an effective topical humectant and is a common ingredient in skin-care products.

In 2003, the FDA approved hyaluronan injections for filling soft tissue defects and they can be adopted in folds and wrinkles reduction, lip augmentation and scars removal.

Equine applications:

Hyaluronan is used in treatment of articular disorders in horses such as carpal and fetlock joint dysfunction, synoyitis and equine osteoarthritis, in particular for racing horses or work horses. It can be injected directly into an affected joint, or intravenously for less localized disorders. It may cause mild heating of the joint if directly injected, but that does not affect the clinical outcome. Intra-articular administered medicine can be fully metabolized within a week.

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